|Lay abstracts on BCERP research|
Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression
Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression. Xuezheng Sun, Patricia Casbas-Hernandez, Carol Bigelow, Liza Makowski, D. Joseph Jerry, Sallie Smith Schneider and Melissa A. Troester.
Increased body fat is a risk factor for an aggressive type of breast cancer called basal-like breast cancer. It is believed that in obese women, inflammatory cells in the breast influence the connection between obesity and breast cancer risk. Obesity was defined using Body Mass Index (BMI): normal weight was defined as BMI ≤ 25; overweight was BMI 25-29.9; and obese was BMI ≥ 30. The purpose of this study was to examine thousands of markers to identify those that are different between obese and normal weight women. Using donated breast tissue from women that were having breast reduction surgery, we found 760 markers that were different between obese and normal-weight women. Several of the markers were genes that can cause inflammation. In agreement with this connection, obese women had higher numbers of inflammatory cells. It is important to study how these changes in cells and markers affect breast cancer growth. Full article
|Last updated July 30, 2012|