As featured in the latest NIEHS Research Brief and this month's NIEHS Environmental Factor,
research led by Dr. Rebecca Fry has shown that blocking the
glucocorticoid receptor pathway in a chick embryo model prevents birth
defects induced by exposure to arsenic. These findings were the result
of a novel systems biology approach combining computational analysis
with laboratory testing to predict and identify key biological pathways
involved in environmentally-induced birth defects.