|Genomic and genetic analysis of liver and kidney toxicity of Trichloroethylene|
The need to account for genetic differences among humans in cancer susceptibility and risk assessment is becoming ever more evident to both the scientific community and regulatory agencies. Dr. Rusyn's lab uses Trichloroethylene (TCE), a man-made, industrial chemical that has become one of the nation's most prevalent groundwater pollutants, as a model environmental contaminant that individuals may respond to differently after exposure, but for which genetic factors are not being fully considered in risk assessment.
Previous research from Dr. Rusyn's lab established that the genetic makeup of the host plays a key role in metabolism of TCE and its biological effects in mouse liver. Dr. Rusyn and his team are working to elucidate the genetic controls underlying species- and organ-specific metabolism and toxicity of TCE. Using genetically diverse inbred mouse strains, his team will assess inter-individual differences in TCE metabolism by collecting time course, dose-response, and repeat dose data on TCE metabolites in blood and tissues. These data will be used to investigate the genetic causes of variation in the metabolism of TCE, a step crucial for understanding the potential for TCE-induced adverse health effects in a heterogeneous human population.
This research is supported by a grant from the National Institute of Environmental Health Sciences (#P42ES005948).
|Last updated January 29, 2013|