|Pauline Lund, PhD|
Cell & Molecular Physiology
Pauline Lund's Biosketch
Pauline Lund's website
REACH NC (Collexis) Research Profile
|1979||University of Newcastle upon Tyne||PhD, Gastrointestinal Endocrinology|
|1975||University of Newcastle upon Tyne||BSc, Physiology|
Growth factor, cytokine and nutrient interactions with particular emphasis on their role in the gastrointestinal tract, stem cells and inflammation associated disease. Her work has focused on a) elucidating the role of insulin/insulinlike growth factors in normal maintenance and renewal of the epithelial lining of the gastrointestinal tract, survival of stem cells and initiation or progression of cancerous lesions b) defining the role newly discovered suppressors of cytokinesignaling as tumor repressors c) defining the role of obesity and inflammation in cancer risk d) defining the role of commensal microflora in obesity, gastrointestinal growth and cancer. Dr. Lund’s research uses transgenic and gene knockout mouse models, mouse models of disease, germ free mice and in vitro systems as well as translating the research to human populations using epidemiological approaches. New approaches include the development of animal models with green-fluorescent protein labeled stem cells as a method to track stem cells in vivo and isolate and characterize them in vivo. In addition carbon-nanotube based X-ray imaging methods and ‘cancer’ enzyme activated molecular probes are also used for in vivo detection of disease.
|Ding S, Chi MM, Scull BP, Rigby R, Schwerbrock NMJ, et al. (2010)|
High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse.
PLoS ONE: vol.5(8), p.e12191.
|Zhang H, Morgan D, Cecil G, Burkholder A, Ramocki N, Scull B, Lund PK. (2008)|
Biochromoendoscopy: molecular imaging with capsule endoscopy for detection of polypoid lesions in the GI tract..
Gastrointestinal Endoscopy: vol.68(3, p.520-7.
|Newton VA, Ramocki NM, Scull BP, Simmons JG, McNaughton K, Lund PK. (2010)|
Suppressor of cytokine signaling-2 gene disruption promotes ApcMin/+ tumorigenesis, serine 727 phosphorylation of STAT3, and AP-1 activation.
J Pathol.: vol.176(5), p.2320-32.
|Ramocki NM, Wilkins HR, Magness ST, Lee GH, Simmons JG, Scull BP, McNaughton K, Lund PK. (2008)|
Insulin receptor substrate 1 deficiency promotes apoptosis of genetically damaged crypt stem cells and protects against APCMin/+ intestinal tumors.
Endocrinology: vol.149(1), p.261-7.
|Rigby RJ, Scull B, Simmons JG, Greenhalgh C, Alexander W, Lund PK. (2007)|
Suppressor of cytokine signaling (SOCS3) limits damage-induced crypt hyperproliferation and inflammation-associated tumorigenesis in the colon.
Oncogene: vol.26, p.4833-41.