Since its inception under Dr. Harry Guess, the Center has attracted world-class faculty members and doctoral students. Our current core of five faculty have unparalleled expertise in pharmacoepidemiology and comparative effectiveness, including advanced methods, meta-analysis of health-care data and risk assessment. Our students are selected for the combination of scientific, intellectual and management skills that will make them future leaders in the health care and pharmaceutical industries.
Til Stürmer, MD, PhD, is director of the Center for Pharmacoepidemiology and professor/head of the pharmacoepidemiology program in the Department of Epidemiology. Dr. Stürmer has a dual focus in epidemiologic methods and clinical epidemiology. His research in epidemiologic methods includes the development of more efficient matching strategies in genetic epidemiology; measurement error correction methods in case-control studies; the value of propensity scores for pharmacoepidemiologic studies; and the novel integration of ideas from measurement error correction and propensity score analysis to improve control for confounding by medication-use choices using data from validation studies. His research in clinical epidemiology covers many topics, including nephro- and cardiovascular toxicity of paracetamol and non-steroidal anti-inflammatory drugs; chemoprevention of colorectal cancer and dementia with non-steroidal anti-inflammatory drugs; determinants of antibiotic resistance; and hormone therapy, pain and sub-clinical inflammation in osteoarthritis.
M. Alan Brookhart, PhD, is associate professor of epidemiology. His methods-oriented health-care epidemiologic research focuses primarily upon the development and application of novel statistical methods and study designs for comparative effectiveness research using large health-care utilization databases. He has made significant contributions to the development of instrumental variable approaches that can be used to estimate causal effects in the presence of unmeasured or poorly recorded confounding variables. His approach uses differences in prescribing patterns between physicians as the basis of a natural experiment. His work also includes the development of propensity score and marginal structural model methodology and new epidemiologic approaches for studying adherence and use of health-care services. He is interested in comparative effectiveness of medications in elderly patients, particularly those with inflammatory conditions and end-stage renal disease.
Alice White MSPH, PhD, is visiting professor of pharmacoepidemiology in the epidemiology department. From 2001 to 2011, she was vice president of the Worldwide Epidemiology Department at GlaxoSmithKline Pharmaceuticals, where she headed a global department of 75 epidemiologists, analysts and support staff, with headquarters in North Carolina and offices in Philadelphia, London, Singapore, Tokyo and Rio de Janeiro. She was responsible for research and development epidemiologic strategy and use of observational data across the development continuum to support disease understanding and decision-making, and for the design and management of large post-marketing safety studies, including GSK's prospective pregnancy registries. She was a member of the Orange County, N.C., Board of Health from 2000 to 2006, and its chair from 2003 to 2004. She has authored numerous publications and scientific presentations, primarily in the cardiovascular and HIV epidemiology areas.
Michele Jonsson-Funk, PhD, is research professor of epidemiology. She is a pharmacoepidemiologist with a particular interest in epidemiology methods. Her work focuses on evaluating the application of doubly robust estimation methods to comparative effectiveness research and safety in observational data. Her research spans a number of substantive areas, including antiretroviral treatment for HIV, cardiovascular disease, cancer and the effect of OTC analgesics on pregnancy outcomes. As director of the Methods Core at the Center for Women's Health Research, she advises clinical and/or junior investigators in women's health research who do not have the training or experience with analytic methods to develop and implement analysis plans independently.
Charles Poole, ScD, is associate professor of epidemiology. Dr. Poole has more than 30 years' experience as an epidemiologic researcher and methodologist. He has published, taught and lectured widely on a broad range of applied and theoretical topics on research methods in nearly every substantive area of epidemiologic research. His areas of special expertise include study design, data collection, statistical analysis, risk assessment, systematic review and meta-analysis.
|Last updated September 11, 2012|